Activity of clove plant extract on histopathological changes of testes tissue in adult white rats.

	Activity of clove plant extract on histopathological changes of testes tissue in adult white rats.
journal of kerbala university
Article 1, Volume 10, Issue 2, 2014, Pages 255-262 PDF (0 K)
Abstract
this search aimed to study the pathological changes that happen in testicular tissue of white rats males by toxic action of mitomycin-c drug and inhibited that effect by using of methanolic water extract of clove. The adult male of white rats treated by dose 2 mg/kg from body weight of drug MMC for one week period to detect the effect of drug on the testis tissue, while the other groups of the rats had been gavaged with drug MMC in same dose interference with plant extract in concentration about 500 mg/kg from body weight for different period of time, one week, two weeks, three weeks, four weeks and five weeks to know the accumulative effects of clove extract and drug action on the testis tissue. The result of the oral gavage for one week of the drug had been showed, appear intercellular spaces between seminiferous tubules and lead to degeneration in spermatogenesis, disappear the sperms in tubule cavity, congestion and absence most of leydig cells compared with negative control , that improve the drug has toxic effect on testis tissue , it lead to pathological changes in that tissue. While the results of interference treatment of the drug and plant extract for five weeks was possessed a good improvement without any pathological tissue changing and testis tissue return to normal position compared with positive control .This result improve clove extract has antioxidant activity

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