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Construction of New Ethambutol Selective Electrodes for Determination Ethambutol in Pharmaceutical Drugs | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 21, Issue 6, 2010, Pages 170-178 | ||
| Author | ||
| Nabil S. Nassory | ||
| Abstract | ||
| Ethambutol selective electrodes were constructed based on ethambutol-phosphotungstate (EMB-PT) complex with different plasticizers; di-butyl phosphate (DBP), tri-butyl phosphate (TBP), di-butyl phthalate (DBPH), o-nitro phenyl octyl ether (NPOE) and di-octyl phthalate (DOPH). The electrodes based on DBP, TBP and DOPH plasticizers gave slopes near to Narnistain slope which are 27.5, 25.2 and 34.5 mV/decade with detection limit of 1.9x10-5 M and concentration range 10-1 to 10-4 M and pH range 3.0 – 8.0. The electrodes based on DBPH and NPOE showed non-Nernistain slopes, 21.5mV/decade for both plasticizers. Interfering of some cations was investigated and shows no interfering with electrodes response. Potentiometric methods were used for measuring ethambutol in pharmaceutical drugs (tablets) and the electrode based on DOPH was used for determination. The recovery obtained from measuring was in good agreements with that given in British Pharmacopeias. | ||
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