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OMENTIN-1 LEVEL IN MIDDLE AGE WOMEN WITH HYPOTHYROIDISM AND THEIR RELATIONS TO RISK FACTORS OF CARDIOVASCULAR DISEASE | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 12, Issue 3, 2014, Pages 273-278 | ||
| Author | ||
| Salma A. Abbas | ||
| Abstract | ||
| Background:Omentin-1 is fat deposition-specific adipokine that is highly and selectively expressed in visceral adipose tissue. Low circulating levels of Omentin-1 have been associated with endothelial dysfunction and cardiovascular disease. Abnormalities of lipid metabolism associated with subclinical and overt hypothyroidisms patients, low Omentin-1 level can affect risk factors for cardiovascular disease. Objective:To determine the differences in the levels of Omentin-1 in middle age women with subclinical and overt hypothyroidisms and correlate its level with parameters which considered risk factor for cardiovascular disease. Methods:Ninety middle age women divided into three groups as follows: group I consisted of 30 healthy women as a control subject, group II comprised 30 women with subclinical hypothyroidisms, group III include 30 women with overt hypothyroidisms, serum of Omentin-1, high sensitive c-reactive protein and lipid profile levels were evaluated in patients and control groups. Results:Serum omentin-1 levels were significant decreased in patients with subclinical and overt hypothyroidisms compared with control group. Significant negative correlation between omentin-1 and thyroid-stimulating hormone, high sensitive c-reactive protein, total cholesterol, atherogenic index in patients was found. Significant positive correlation was observed between Omentin-1 and high-density lipoprotein in the patients. Conclusion:we conclude that serum Omentin-1 levels were decrease in middle age women with hypothyroidism and its correlate with altering lipid profile, high levels of atherogenic index and high sensitive c-reactive protein, all of these conditions is correlated with cardiovascular disease, so Omentin-1 in hypothyroidism patients is a risk factor for cardiovascular disease, our suggestion that possible follow up serum lipid profile and omentin-1 monthly for middle age women to prevent cardiovascular disease. Keywords:Omentin-1, lipid profile, hypothyroidism disease | ||
| Keywords | ||
| Omentin; Lipid profile; hypothyroidism disease | ||
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