Serum Interleukine 35 in Iraqi female patients with newly diagnosed of rheumatoid arthriti

F. Al-Tai, Anwar

	Serum Interleukine 35 in Iraqi female patients with newly diagnosed of rheumatoid arthriti
Journal of the Faculty of Medicine
Article 1, Volume 56, Issue 3, 2014, Pages 322-324
Author
Anwar F. Al-Tai
Abstract
Background: Rheumatoid arthritis (RA) characterized by local and systemic effects of inflammation has a wide range of biochemical markers implicated directly or indirectly to its pathogenesis. Objective: To evaluate interlukine 35 (IL-35) in Iraqi females with newly diagnosed RA and to assess its contribution in the disease process. Patients and method: Serum of (55 Females) of newly diagnosed RA and 23 healthy Females were used to estimate their interlukine levels. Results: Females of RA showed a significant increase in the levels of interleukine 35(IL-35) and in the levels of High Sensitivity C-Reactive Protein (hs CRP). While there were no significant changes in the level of alkaline phosphatase (ALP) and calcium (Ca). The correlation between IL-35 and each of hs CRP, ALP and Ca (-ve) were non-significant (r = -0.066, -0.04271 and -0.103) respectively. Conclusion : This is the first study to show the elevation of serum levels of IL-35 in Iraqi female patients with newly diagnosed RA which indicates that IL- 35 may be a good biomarker for early RA. Key Words: Rheumatoid arthritis (RA), Interleukin 35 (IL-35), High sensitivity C- reactive protein (hs CRP), Calcium (Ca), alkaline phosphatase (ALP).
Keywords
Rheumatoid arthritis; Interleukin; High sensitivity C; reactive protein; Calcium; alkaline phosphatase; ATP

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