Serum Progesterone &CA125 Levels as an Aid in the Prediction of Ectopic &Intrauterine Pregnancy

M. Al-Bayati, Maha; Madany A. Qader, Manal; Hadi Salma, Jinan

	Serum Progesterone &CA125 Levels as an Aid in the Prediction of Ectopic &Intrauterine Pregnancy
Iraqi Postgraduate Medical Journal
Article 1, Volume 14, Issue 1, 2015, Pages 7-13 PDF (0 K)
Authors
Maha M. Al-Bayati; Manal Madany A. Qader; Jinan Hadi Salma
Abstract
ABSTRACT: BACKGROUND : Prompt diagnosis of ectopic pregnancy is a difficult dilemma, and reliable predictors for diagnosis and differentiation of ectopic pregnancy from early pregnancy miscarriage are needed. OBJECTIVE: To evaluate the diagnostic value of serum progesterone and CA-125 levels in ectopic pregnancy and early intra uterine miscarriage. Study design: A prospective case control study Setting: The study was carried out in the department of obstetrics and gynecology of AL-Yarmouk teaching hospital (Baghdad – Iraq) from February 2011 to February 2012 PATIENTS AND METHODS: This study was carried out on sixty pregnant women in their first trimester. Twenty women diagnosed as unruptured ectopic pregnancy; treated by laparotomy ,twenty women diagnosed as inevitable miscarriage; treated by curettage and twenty women with healthy pregnancy of a comparable gestational age as control group; follow up of this group was done to ascertain uneventful pregnancy with no complications. We compared the serum levels of progesterone and CA-125 in all groups at the time of presentation and 24h after surgical intervention in first and second groups. RESULTS : There was a significant decrease in mean post operative progesterone level in women with ectopic pregnancy and miscarriage groups with significant difference (P<0.0001). The study observed that the mean level of progesterone in women with ectopic group (6.76±3.63 ng/ml) was lower than that in miscarriage group (15.17±6.01 ng/ml) and control group (17.58±4.57 ng/ml) with significant difference (P<0.0001). This study also observed that the mean level of CA-125 in women with miscarriage group (117.07±94.30 U/ml) was higher than that in ectopic group (38.11±28.79 U/ml) and control group (30.51±16.10 U/ml) with statistically significant difference (P<0.0001). There was a significant decrease in mean level of post operative CA-125 in women with ectopic pregnancy and miscarriage groups with significant difference (P<0.0003). CONCLUSION: Combined measurement of both serum progesterone and CA-125 can be sensitive predictors in diagnosis and differentiation of ectopic pregnancy from inevitable miscarriage and normal pregnancy.
Keywords
KEY WORDS; Miscarriage; Progesterone

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