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The hypoglycemic effect of Fenugreek (Trigonella foenum-gracecum) sead extract in experimentally diabetic rats | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 25, Issue 4, 2014, Pages 1-8 | ||
| Author | ||
| Yasir Hussein Al-Juraisy | ||
| Abstract | ||
| This study was designed to investigate the hypoglycemic effect of ethanolic extract of fenugreek seed (Trigonella-foenum graecum) in normal and streptozotocin-induced diabetic rats. Seeds extract was orally administered with 350 mg/kg for 21 days. Body weights and serum glucose levels were weekly checked in all treated and untreated groups. Administrations of the extract alleviated body weight loss and significantly decreased serum glucose levels in diabetic rats, whereas it increased serum insulin in diabetic rats but not in normal rats (P < 0.05). A comparison was made between the action of fenugreek seed extract and glibenclamide (600 μg/kg), the known antidiabetic drug. The antidiabetic effect of the extract was similar to that observed for glibenclamide. It is concluded that the plant should be considered as an excellent candidate for future studies on diabetes mellitus. | ||
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