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Thermodynamic Studies for the Interaction of Some Anticoagulant Drugs with Albumin | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 18, Issue 1, 2015, Pages 20-27 | ||
| Authors | ||
| Elham M. Al-Rufaie; Zahraa H.Al-Shareefi | ||
| Abstract | ||
| Fluorescence spectroscopy in combination with UV- vis absorption spectroscopy was employed to investigate the binding of some important anticoagulant drugs warfarin, heparin and aspirin to human serum albumin under physiological conditions. Scatchard equation provide a measure of the binding affinity between these three drugs individually and albumin. The results of thermodynamic parameters ∆G, ∆H, and ∆S at three different temperatures indicate that the hydrophobic interaction plays a major role for the interaction between each of these drugs and albumin. | ||
| Keywords | ||
| Albumin interaction; Anticoagulant drugs; thermodynamic parameters | ||
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