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The effect of the phenolic and other active compounds of the alcohol and acid extracts of cinnamon on some of the Biochemical Parameters of induced diabetes mellitus | ||
| Jornal of Biotechnology Research Center | ||
| Article 1, Volume 9, Issue 1, 2015, Pages 24-36 | ||
| Authors | ||
| Hayder Turki AL-Musawi; Mohammed Ibrahem AL-Tai; Muna Turki AL-Musawi | ||
| Abstract | ||
| The phenolic compound and other active compounds were extracted from cinnamon, in an attempt to produce a drug from Medical and herbal Plants for the diabetes on rats. The extraction process included two methods the first carrid out with 2% v/v acetic acid and propanol, and in the second process 70% v/v ethanol and chloroform were used. In the detection of extracts it was noticed that both conteined phenols, flavonoids, tannins and Glycosidesand Coumarins, while the saponin showed up only in the alcoholic extract of cinnamon. The phenolic compounds in the extracts of cinnamon were determined by using Ultraviolet Spectroscopy (UV) and other function groups such as phenols, aldehyedes, estars, hydrocarbons, alcohols and carboxylic compounds were diagnosed by using Infrared spectroscopy (IR). The study of the half lethal dose (midl lethal) (LD50) was also examined by testing the toxicity of the two cinnamon extracts. Rats were used as laboratory animals in conducting the experiments. The rats were fed by the dose (100, 200, 300,400, 500 mg / kg of body weight). The results have shown that there is no toxic effect in the cinnamon extracts. Similar concentrations were used to determine the effective dose of the extracts in reducing the level of glucose in the blood of healthy animals. The dose (300) mg / kg of body weight of the animal body has proved to be the the most efficient as it decreased. The fasting glucose (Glu) serum consider by following of the cinnamon extracts with the adopted groups during the duration of (30) days in comparison with the control group (the infected) and outperformed the treated given Glibenelinide (daonil) group.The biochemical tests showed that the serum concentrations of each of cholesterol (TC),Triglyceride (TG), low density lipoprotein (LDL-C) was lowered in each of the groups treated with both cinnamon extracts in comparison with the positive groups (infected) throughout the duration (30) days and overcome the daonil treated group. However the serum high density lipoprotein (HDL-C) level was increased in cinnamon extract treated groupsand decreased in the control group (infected). The serumconcentrations of enzymes (GOT) and (GPT) were measured to test the liver function after where their levels were lowered after (30) days in the cinnamon extracts administered groups compared with the two other groups, the control (positive) and the Daonil. The Urea and Creatinine levels were measured to determine or test the kidney functions, where it was observed as from the early days of the infection in that animals infected by induced diabetes developed symptoms of the illness, apparent in the high levels of urine which affected the functions of kidney, but the long duration (30 days) of treatment with these extracts of cinnamon proved their efficiency over the control group (positive). | ||
| Keywords | ||
| cinnamon; phenolic compound and active compounds extract; detection for active compounds; Diabetes; induced diabetes; biochemical tests | ||
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