Saber G. Al-Deresawi, M., Hussein Moyet AlFaisal, A. (2015). Two novel missense mutations in exon 9 of TPO gene in Polycystic Ovary Syndrome patients with hypothyroidism. , 9(1), 30-37.
Mahdi Saber G. Al-Deresawi; Abdul Hussein Moyet AlFaisal. "Two novel missense mutations in exon 9 of TPO gene in Polycystic Ovary Syndrome patients with hypothyroidism". , 9, 1, 2015, 30-37.
Saber G. Al-Deresawi, M., Hussein Moyet AlFaisal, A. (2015). 'Two novel missense mutations in exon 9 of TPO gene in Polycystic Ovary Syndrome patients with hypothyroidism', , 9(1), pp. 30-37.
Saber G. Al-Deresawi, M., Hussein Moyet AlFaisal, A. Two novel missense mutations in exon 9 of TPO gene in Polycystic Ovary Syndrome patients with hypothyroidism. , 2015; 9(1): 30-37.

Two novel missense mutations in exon 9 of TPO gene in Polycystic Ovary Syndrome patients with hypothyroidism

Jornal of Biotechnology Research Center
Article 1, Volume 9, Issue 1, 2015, Pages 30-37
Authors
Mahdi Saber G. Al-Deresawi; Abdul Hussein Moyet AlFaisal
Abstract
This study was reflected on the relationship between the polycystic ovary syndrome (PCOS) and the genetic alternations in TPO gene. Fifty infertile Iraqi women with PCOS and 20 healthy women were included in this study, Blood samples were collected from the Infertility center of AL-Yarmok Teaching Hospital in Baghdad, during the period from November, 2010 to May, 2011. The age of infertile and fertile women was ranged from 16 to 45 years. The results of hormonal assay were as follows: There is significant (P ≤0.05) decrease in E2 and FSH levels in PCOS women and fertile women, There is significant (P ≤0.05) increase in LH levels in PCOS women and fertile women. There is no significant differences in Testosterone levels and the ratio of LH/FSH was ≥1.5. The molecular study was focused on the 18% of PCOS women with hypothyroidism. By sequencing for 27 samples; two novel different mutations were identified in the reading frame of the TPO gene in transcript variant of exon 9: c.1471delC (deletion C in codon 460) and c.1481delC (deletion C in codon 464). The percentage of mutations c.1481delC and c.1471delC recorded 55% and 44% of PCOS with hypothyroidism; respectively.
Keywords
missense mutations; TPO gene; Polycystic Ovary; hypothyroidism; TPO
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