Profile of Some Cytokines in Sera of Children with Autism Syndrome

M. Halboot, Kamil; K.Melconian, Alice; AL- Saffar, Jenan

	Profile of Some Cytokines in Sera of Children with Autism Syndrome
Iraqi Journal of Science
Article 1, Volume 56, Issue 1, 2015, Pages 125-131
Authors
Kamil M. Halboot; Alice K.Melconian; Jenan AL- Saffar
Abstract
Autism spectrum disorder (ASD) is a spectrum of behavioral anomalies characterized by impairment in social interactions and communication deficits. A potential role for immune dysfunction has been suggested in ASD. To test this hypothesis, certain cytokines: IL-2, IL-10, IL-12, IL-17A and IFN-γ were investigated in serum of all participants. The study includes: 39 child (male and female) aged < 5 to10 years with confirmed diagnosis of autism using standard assessment, age and gender matched 24 confirmed healthy children and 19 non autistic siblings used as controls. Serum was isolated and cytokines were detected using enzyme linked immunosorbent assay (ELISA). The observations indicate a significant increase (P < 0.05) in autistic patients serum levels of IL-10 compared with healthy control, but with lack of significant difference with their related non autistic siblings. Whereas detection of IL-12 and IFN-γ in the autistic patients serum showed significantly decrease level (P < 0.05) compared with healthy control, but with lack of significant difference with their related non autistic siblings. On the other hand, detection of IL-2 and IL-17A results showed no significant (P > 0.05) differences compared with healthy control and non autistic siblings.
Keywords
Autism spectrum disorder; cytokines; enzyme linked immunosorbent assay

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