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The impact of inflammation on Resistin, IL-6 andCRP in Acute Myocardial Infarction Patients. | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 53, Issue 2, 2011, Pages 216-220 | ||
| Authors | ||
| Hamid K. Sachit AL-Janabi; Hadef D. EL-Yassin; Ammal E. Ibrahim | ||
| Abstract | ||
| Background: Inflammation contributes across the spectrum of cardiovascular disease, including the earliest steps in atherogenesis. Myocardial Infarction (MI) is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque. It has been suggested that the adipose tissue may play an important role in mediating this chronic inflammatory process, human resistin, is a 12.5-kDa protein, it found in the inflammatory zone. Interleukin-6 (IL-6) is a pro-inflammatory cytokine, it secreted by T cells and macrophages to stimulate immune response. C-reactive protein (CRP) is a protein found in the blood, the levels of CRP rise in response to inflammation.Objective: to determine the role of Resistin in Acute myocardial infarction patients and its effects on IL-6 and CRP.Patients and Methods: The study included 50 patients with Acute Myocardial Infarction and 40 healthy subject as control, levels of resistin, Interleukin-6 (IL-6) and CRP were measured.Results: The levels of resistin, IL-6 and CRP were significantly elevated with (p<0.001). There was positive correlation between resistin with IL-6 and CRP in acute myocardial infarction patients.Conclusions: There was significantly increasing in levels of resistin, in acute myocardial infarction patients and this increasing may be related to inflammation. Resistin positively correlated with pro- inflammatory factor (IL-6 and CRP) so it have inflammation properties may consider a cardiovascular risk factor. | ||
| Keywords | ||
| resistin; CRP and Acute Myocardial Infarction | ||
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