THE MUTAGEN AND ANTIMUTAGEN ACTIVITY OF CARNOSINE ASSESSED  BY BACTERIAL SYSTEM 1:  THE MUTATION CAPABILITY OF CARNOSINE  AND SOME MAILLARD REACTION PRODUCTS

D. Salman, D.; K. Al-darwash, A.

	THE MUTAGEN AND ANTIMUTAGEN ACTIVITY OF CARNOSINE ASSESSED BY BACTERIAL SYSTEM 1: THE MUTATION CAPABILITY OF CARNOSINE AND SOME MAILLARD REACTION PRODUCTS
IRAQ JOURNAL OF AGRICULTURE
Article 1, Volume 14, Issue 4, 2009, Pages 0-0
Authors
D. D. Salman; A. K. Al-darwash
Abstract
The effect of mutagencity, toxicity of carnosine and products from carnosine and amino acid reaction with fructose (milliard reaction) were studied by using bacterial system (G – system) that consisted of three isolates. namely, Bacillus spp ( G3), Arthrobacter spp. (G12), Brevibacterium spp. (G27) These isolate were characterized by sensitivity to both streptomycin and rifampcin. The Survival index (Sx) and induction of resistant mutant of streptomycin and rifampcin were considered in this study. Different concentrations of carnosine and milliard reaction products were used to study their genetic and cellular toxicity in the above mentioned bacterial systems. The study revealed that: The purified carnosine from chicken pectoral muscle with concentration of 50, 100 and 250 g/ml showed neither cytotoxic nor mutagenic effects in bacterial systems. The products of lysine-fructose reaction at concentrations of 1 and 5% showed resistance toward mutation of streptomycin in the three bacterial isolates, and mutant resistance to rifampcin in bacterial isolates G12 and G27. However, products of argenine-fructose reaction at concentrations of 1 and 5% showed only mutant resistance to streptomycin in the three isolates, and the mutagenic activity of the products of Carnosine- fructose reaction was disappeared

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