Sh. Al-Obaidy, G., Kh. Kh. Al-Dulymi, H., A. Abed, M. (2024). SYNTHESIZING PD (II), RU (II) BENZONITRILE-PHENOTHIAZINE DERIVATIVE COMPLEXES AND INVESTIGATING THEIR ANTIBACTERIAL ACTIVITY AND REMOVAL OF SOME HEAVY METALS IN ENVIRONMENTAL SYSTEMS. , 22(2), 1082-1093. doi: 10.32649/ajas.2024.184468
G. Sh. Al-Obaidy; H. Kh. Kh. Al-Dulymi; M. A. Abed. "SYNTHESIZING PD (II), RU (II) BENZONITRILE-PHENOTHIAZINE DERIVATIVE COMPLEXES AND INVESTIGATING THEIR ANTIBACTERIAL ACTIVITY AND REMOVAL OF SOME HEAVY METALS IN ENVIRONMENTAL SYSTEMS". , 22, 2, 2024, 1082-1093. doi: 10.32649/ajas.2024.184468
Sh. Al-Obaidy, G., Kh. Kh. Al-Dulymi, H., A. Abed, M. (2024). 'SYNTHESIZING PD (II), RU (II) BENZONITRILE-PHENOTHIAZINE DERIVATIVE COMPLEXES AND INVESTIGATING THEIR ANTIBACTERIAL ACTIVITY AND REMOVAL OF SOME HEAVY METALS IN ENVIRONMENTAL SYSTEMS', , 22(2), pp. 1082-1093. doi: 10.32649/ajas.2024.184468
Sh. Al-Obaidy, G., Kh. Kh. Al-Dulymi, H., A. Abed, M. SYNTHESIZING PD (II), RU (II) BENZONITRILE-PHENOTHIAZINE DERIVATIVE COMPLEXES AND INVESTIGATING THEIR ANTIBACTERIAL ACTIVITY AND REMOVAL OF SOME HEAVY METALS IN ENVIRONMENTAL SYSTEMS. , 2024; 22(2): 1082-1093. doi: 10.32649/ajas.2024.184468

SYNTHESIZING PD (II), RU (II) BENZONITRILE-PHENOTHIAZINE DERIVATIVE COMPLEXES AND INVESTIGATING THEIR ANTIBACTERIAL ACTIVITY AND REMOVAL OF SOME HEAVY METALS IN ENVIRONMENTAL SYSTEMS

Anbar Journal of Agricultural Sciences
Volume 22, Issue 2, December 2024, Pages 1082-1093    PDF (662.83 K)
Document Type: Research Paper
DOI: 10.32649/ajas.2024.184468
Authors
G. Sh. Al-Obaidy1; H. Kh. Kh. Al-Dulymi1; M. A. Abed2
1Department of Chemistry, College of Science, University of Anbar
2Department of Food Sciences, College of Agriculture, University of Anbar
Abstract
First, phenol thiazine is reacted with sodium metabisulphite, sodium cyanide, and 4-Formylbenzonitrile to yield the appropriate nitrile. In this study, 4-(cyano(10H-phenothiazin-10-yl)methyl)benzonitrile, a phenothiazine derivative, was synthesized. The stereoscopic shape of the complexes formed around the ionic centers was determined using spectroscopic and physical techniques, including elemental analysis, 1H-NMR and 13C- NMR spectra, FTIR, UV-Vis, metal content, and conductance measurements. After synthesizing the derivatives of the complexes the biological activity of the prepared ligand and its complexes was studied to estimate their potential antimicrobial activity. In general, tests show the ligand and its complexes having good activity against bacteria. The prepared ligand was used to remove heavy metals causing water pollution. Among the heavy elements studied were zinc, lead, and copper. The findings suggest that the prepared complexes may be used to lower concentrations of these elements in water and mitigate their impact on the environment.
Keywords
Transition metal complexes; physical techniques; Spectral characterization
References
  1. Abdullah, S. A., Mohammed, A. S., and Othman, E. A. (2020). Preparation and characterization of compounds for di thiocarbamate derivatives and their use as scavenger for some heavy metals in environmental systems. Samarra Journal of Pure and Applied Science, 2(3): 19-30.‏
  2. Al-Obaidy, G. S., and Awad, S. S. (2023, September). Co2+, Cu+ 2, Ni+ 2, Au+ 3, complexes with ((Z)-1-(3-chlorophenyl)-N-(4-methoxy-2-nitrophenyl) methanimine) ligand, formation and spectral characterization. In AIP Conference Proceedings, 2839(1). https://doi.org/10.1063/5.0167646.
  3. Alwani, M. V., Cholkar, K., Nayak, A. N., and Gowda, N. M. M. (2005). Synthesis and characterization of mercury (II) bromide-phenothiazine complexes (Doctoral dissertation, Western Illinois University).‏
  4. Amin, A., Qadir, T., Sharma, P. K., Jeelani, I., and Abe, H. (2022). A review on the medicinal and industrial applications of N-containing heterocycles. The Open Medicinal Chemistry Journal, 16(1) http://dx.doi.org/10.2174/18741045-v16-e2209010.
  5. Antonescu, S., Bacu, E., STĂNICĂ, N., Oprea, O., and Guran, C. (2010). New complex compounds of Fe (III) and Cu (II)-with phenothiazines derivatives. University Politehnica of Bucharest scientific bulletin series b-chemistry and materials science, 72(4): 145-154.‏
  6. Arulmurugan, S., Kavitha, H. P., and Venkatraman, B. R. (2011). Synthesis, characterization and study of antibacterial activity of some novel tetrazole derivatives. Orbital: The Electronic Journal of Chemistry, 2(3): 271-276.‏
  7. Chigari, S. S., and Kumar, V. (2023). Ultrasonic radiation assisted synthesis of (CH3NH3) 2CuCl4, CH3NH3PbCl3, and CH3NH3SnCl3 perovskites for energy application. Journal of Hazardous Materials Advances, 12: 100368.‏ https://doi.org/10.1016/j.hazadv.2023.100368.
  8. Choi, J. H., Lamshöft, M., Zühlke, S., Abd El-Aty, A. M., Rahman, M. M., Kim, S. W., ... and Spiteller, M. (2014). Analyses and decreasing patterns of veterinary antianxiety medications in soils. Journal of Hazardous Materials, 275: 154-165.‏ https://doi.org/10.1016/j.jhazmat.2014.05.005.
  9. Deghadi, R. G., Mohamed, G. G., and Mahmoud, N. F. (2022). Bioactive La (III), Er (III), Yb (III), Ru (III), and Ta (V) complexes of new organometallic Schiff base: Preparation, structural characterization, antibacterial, anticancer activities, and MOE studies. Applied Organometallic Chemistry, 36(6): e6675.‏ https://doi.org/10.1002/aoc.6675.
  10. Gopi, C., and Dhanaraju, M. D. (2019). Recent progress in synthesis, structure and biological activities of phenothiazine derivatives. Review Journal of Chemistry, 9: 95-126.‏ https://doi.org/10.1134/S2079978019020018.
  11. Hama Salih, Y., N., & B. Ahmad, A. (2024). The Effect Of Domestic Water Filter Types On The Quality Of Drinking Water. Anbar Journal Of Agricultural Sciences, 22(1), 55–66. https://doi.org/10.32649/ajas.2024.183697.
  12. Hannachi, N., Elwej, R., Roisnel, T., and Hlel, F. (2023). Effect of changing anion on the crystalline structure, crystal structure, hirschfield surface, ir and nmr spectroscopy of organic salts and hybrid compounds: C6H4 (NH3) 2Cl2 (I), β-[C6H10N2] 2ZnCl4 (II), respectively. Open Journal of Inorganic Chemistry, 13(1): 1-24.‏ https://doi.org/10.4236/ojic.2023.131001.
  13. Jawad, S. H., and Al-Adilee, K. J. (2023). Synthesis, spectroscopic characterization and biological activities as an anticancer and antioxidant of the Pd (II) and Pt (IV) complexes with a new azo dye ligand derived from 5-methyl imidazole. Journal of Molecular Structure, 1277: 134846. https://doi.org/10.1016/j.molstruc.2022.134846.
  14. Jebril, M. T., N., K. Murad, A., & Boden, R. (2024). Bioremediation Of Cadmium Contaminated Water: Bacterial Accumulation And Surface Complexity By Revibacillus Agri C15 And Brevibacillus Agri C15 Cdr. Anbar Journal Of Agricultural Sciences, 22(1), 217–233. https://doi.org/10.32649/ajas.2024.147810.1166.
  15. Kucková, L., Jomová, K., Švorcová, A., Valko, M., Segľa, P., Moncoľ, J., and Kožíšek, J. (2015). Synthesis, crystal structure, spectroscopic properties and potential biological activities of salicylate‒neocuproine ternary copper (II) complexes. Molecules, 20(2): 2115-2137.‏ https://doi.org/10.3390/molecules20022115.
  16. Leskovac, A., Petrovic, S., Lazarevic-Pasti, T., Krstic, M., and Vasic, V. (2018). Ruthenium (II)-N-alkyl phenothiazine complexes as potential anticancer agents. JBIC Journal of Biological Inorganic Chemistry, 23: 689-704.‏ https://doi.org/10.1007/s00775-018-1560-x.
  17. Mian, M. R., Wakizaka, M., Yoshida, T., Iguchi, H., Takaishi, S., Afrin, U., ... and Yamashita, M. (2021). An unusual Pd (III) oxidation state in the Pd–Cl chain complex with high thermal stability and electrical conductivity. Dalton Transactions, 50(5): 1614-1619.‏ https://doi.org/10.1039/D0DT03848B.
  18. Namiecińska, E., Grazul, M., Sadowska, B., Więckowska-Szakiel, M., Hikisz, P., Pasternak, B., and Budzisz, E. (2022). Arene-ruthenium (II) complexes with carbothiamidopyrazoles as a potential alternative for antibiotic resistance in human. Molecules, 27(2): 468.‏ https://doi.org/10.3390/molecules27020468.
  19. Onoabedje, E. A., Okoro, U. C., Sarkar, A., and Knight, D. W. (2016). Synthesis and structure of new alkynyl derivatives of phenothiazine and phenoxazine. Journal of Sulfur Chemistry, 37(3): 269-281.‏ https://doi.org/10.1080/17415993.2015.1131827.
  20. Periyasamy, K., Sakthivel, P., Venkatesh, G., Vennila, P., Mary, Y. S., and Haseena, S. (2024). Structural and photophysical studies of triphenylamine-based organic dyes for applications in DSSCs: experimental and DFT analysis. Polycyclic Aromatic Compounds, 44(8): 5314-5337.‏ https://doi.org/10.1080/10406638.2023.2264450.
  21. Petrie, B., Barden, R., and Kasprzyk-Hordern, B. (2015). A review on emerging contaminants in wastewaters and the environment: current knowledge, understudied areas and recommendations for future monitoring. Water research, 72: 3-27.‏ https://doi.org/10.1016/j.watres.2014.08.053.
  22. Pratt, M. D., and Beer, P. D. (2004). Heterodinuclear ruthenium (II) bipyridyl-transition metal dithiocarbamate macrocycles for anion recognition and sensing. Tetrahedron, 60(49): 11227-11238. https://doi.org/10.1016/j.tet.2004.08.058.
  23. Ruiz, J., Martínez, M. T., Florenciano, F., Rodríguez, V., López, G., Pérez, J., ... and Hitchcock, P. B. (2003). Insertion Reactions into Pd− O and Pd− N Bonds: Preparation of Alkoxycarbonyl, Carbonato, Carbamato, Thiocarbamate, and Thioureide Complexes of Palladium (II). Inorganic chemistry, 42(11): 3650-3661.‏ https://doi.org/10.1021/ic0300058.
  24. Wilde, M. L., Schneider, M., and Kümmerer, K. (2017). Fenton process on single and mixture components of phenothiazine pharmaceuticals: Assessment of intermediaries, fate, and preliminary ecotoxicity. Science of the total environment, 583: 36-52.‏ https://doi.org/10.1016/j.scitotenv.2016.12.184.
  25. Zhang, M. X., Yang, X., Tan, F., Zhang, H., Zeng, G., Xu, Z., and Liu, S. H. (2023). Synthesis, structure and mechanofluorochromic properties of phenothiazine-S-oxide and phenothiazine-S, S-dioxide derivatives. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 292: 122427.‏ https://doi.org/10.1016/j.saa.2023.122427.
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