Humadi, A., Hamed, R., Awad, H. (2025). The Impact of Two Platelet Concentrates on Healing of Surgically Created Bone Defects in Sheep (Radiological Analysis). , 25(1), 142-150. doi: 10.33899/rdenj.2024.148248.1253
Amina Abdolfattah Humadi; Rayan Salim Hamed; Hayam Nori Awad. "The Impact of Two Platelet Concentrates on Healing of Surgically Created Bone Defects in Sheep (Radiological Analysis)". , 25, 1, 2025, 142-150. doi: 10.33899/rdenj.2024.148248.1253
Humadi, A., Hamed, R., Awad, H. (2025). 'The Impact of Two Platelet Concentrates on Healing of Surgically Created Bone Defects in Sheep (Radiological Analysis)', , 25(1), pp. 142-150. doi: 10.33899/rdenj.2024.148248.1253
Humadi, A., Hamed, R., Awad, H. The Impact of Two Platelet Concentrates on Healing of Surgically Created Bone Defects in Sheep (Radiological Analysis). , 2025; 25(1): 142-150. doi: 10.33899/rdenj.2024.148248.1253

The Impact of Two Platelet Concentrates on Healing of Surgically Created Bone Defects in Sheep (Radiological Analysis)

Al-Rafidain Dental Journal
Article 11, Volume 25, Issue 1, March 2025, Pages 142-150    PDF (666.16 K)
Document Type: Research Paper
DOI: 10.33899/rdenj.2024.148248.1253
Authors
Amina Abdolfattah Humadi* 1; Rayan Salim Hamed1; Hayam Nori Awad2
1Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Mosul, Iraq
2Department of Basic Dental Sciences/College of Dentistry/ University of Duhok, Kurdistan Region, Iraq
Abstract
 The present study aims to assess the density of bone with Concentrated growth factors and advanced plasma-rich fibrin in the bone defects that were created surgically in the sheep’s mandible by the use of radiographic assessment. Materials and methods: Seven defects were made in the bone with 4 mm depth and width on every side of the mandible of the eight sheep, The defects were filled in the following manner: from the proximal to the distal orientation; 1st, 2nd, 3rd, 4th, and the 5th defect was full of CGF on the right side and A-FRF is in the left side, the 6th, and 7th left empty to filled with physiological clot. Densitometric analysis of the defects of the bone was made to measure the bone density of the 4 intervals (3 days, 7 days, 21 days, 28 days), after the surgery. Results: The result of the Densitometric analysis revealed a major distinction between the CGF group and the A-PRF group when compared to the control group at all four intervals with the density of the bone being the highest in the CGF group followed by the A-PRF group and the control group was the least one show improvement in the bone density. Conclusions: The CGF group increased the density of the bone throughout the entire study period as found by densitometric analysis data.
Keywords
Concentrated growth factors; Advanced platelet rich fibrin; Bone density
Supplementary Files
References
  1. Chen Y, Xu J, Huang Z, Yu M, Zhang Y. An Innovative Approach for Enhancing Bone Defect Healing Using PLGA Scaffolds Seeded with Bone Marrow Mesenchymal Stem Cells ( BMSCs ). Nat Publ Gr [Internet]. 2017;(February):1–13.
  2. Lee E, Kim D, Lim H, Lee J, Jung U, Choi S. Comparative evaluation of biphasic calcium phosphate and biphasic calcium phosphate collagen composite on osteoconductive potency in rabbit calvarial defect. 2015;1–7.
  3. Caruana, Andree ; Savina , Daniele; et al . 2019 .From platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical in Modern Surgery . European Journal of Dentistry , Vol.13(2): 280-286.
  4. Lokwani, Bhavna Vasudev; Gupta, Deeksha, et a .2020. The Use of concentrated growth factor in dental implantology: A system review. The Journal of Indian prosthodontics Society.Vol.20 (1): (3-10).
  5. Kalfas, I.H.2001. Principles of bone healing. Neurological focus, Vol.10(4): 1-4.
  6. Li, y; Chen, k; LI, L; Qin, L; Wang, X-L and Lai, Y. 2015. Bone Defect Animal Models for Testing Efficacy of Bone Substitute Biomaterials. Journal of Orthopedic Translation. Vol.4(3): 95-104.
  7. Sartoretto, S. C; Uzeda, M.J; Miguel, F.B; Nascimento, J. R; Ascoli, F. and Calasans-Mia, M. D. 2016. Sheep as an Experimental Model Implant Evaluation.Acta Ortopecica Brasileira. Voi.24: 262-266.
  8. Sitamahalakshmi, K; Bingi, S.K; Kumar, G.K; Bhuvanesh, Y; Sai, S.K and Parkavi, S. 2024. Rejuvenation of Bone Volume with CGF and I-PRF in Intra-Osseous Defects. Bioinformation. Vol.(1): 85.
  9. Preetibhadouria, D.A.S.P; Sharma, C; Sankey Kumar Baidya, D.R.K.S. and Dhimte, S. 2023. Evaluation of Concentrated Growth Factor and Advanced Platelete Rich Fibrin around Peri-implant Tissues in Maxillary Anterior Region. Pakistan Heart Journal.Vol.56(1):644-648.
  10. Stanca, E; Calabriso, N; Giannotti, L; Nitti, P; Stanca, Damiano, F; and Stanca, B. D. C. 2021. Analysis of CGF Biomolecules, Structure and Cell Population: Characterization of the Stemness Features of CGF Cells and Osteogenic Potential. International Journal OF Molecular Science.Vol.22.(16):8867.
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