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Synthesis and Charactrization of some Hetrocyclic Compounds from Ninhydrin and Study of its Effect on Amylase Enzyme in Serum | ||
| Tikrit Journal for Dental Sciences | ||
| Volume 6, Issue 1, June 2018, Pages 44-51 PDF (928.11 K) | ||
| DOI: 10.25130/tjds.6.1.8 | ||
| Author | ||
| Ibtihal Q. Abdalla | ||
| Department of Chemistry, College of Science, Tikrit University, Iraq. | ||
| Abstract | ||
| Ninhydrin is a chemical compound that is commonly used in analytical chemistry. In this research, ninhydrin was utilized to prepare some heterocyclic derivatives. It was reacted with hydrazine to make compound (1), which was the starting material to synthesize other heterocyclic derivatives in this research. These compounds were characterized by (FT-IR) and (H-NMR) techniques. The biological effect of the prepared compounds were tested against the activity of amylase enzyme in serum. These compounds resulted in deactivating the amylase enzyme in a percentage rate of (11.43, 36.49) %, which proves their effectiveness against the enzyme. Introduction:Hetero cyclic compound and their derivatives have an important and fundamental role in many areas, particularly in biological and industrial filed (1). Imidazole, an organic compound that has formula (C3H4N2), is a hetero cyclic compound. Imidazole ring is a part of Histidine's structure. It is also part of the theofylene molecule found in tea leaves and coffee (2). Imidazole is involved in the manufacture of certain anti-cancer drugs (3). B | ||
| Keywords | ||
| hetrocyclic ninhydrin amalysis enzyme | ||
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