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Studying the Effect of the Aqueous Extract of Blackberry Fruits on Liver Tissue in Male Rabbits with Induced Hypothyroidism | ||
| Al-Qadisiyah Journal of Pure Science | ||
| Volume 30, Issue 2, December 2025, Pages 165-178 PDF (570.56 K) | ||
| DOI: 10.29350/qjps.2025.190628 | ||
| Abstract | ||
| This experiment was designed to determine the effect of the aqueous extract of blackberry fruits on the liver tissue of male rabbits with therapeutically induced hypothyroidism. Twenty adult male rabbits were randomly distributed into four equal groups. The first group was treated with water and normal food and was considered a negative control group (G1). The second group was treated with carbimazole (G2). The third group was treated with carbimazole and aqueous extract of blackberry fruits (G3). The fourth group was treated with aqueous extract of blackberry fruits (G4). The results showed a significant decrease at the probability level (p<0.01) in the second group (G2) treated with carbimazole in the concentration of HDL and a significant increase at the probability level (p<0.01) in the concentration of (TC, TG, LDL, VLDL) respectively with an increase in the concentration of the lipase enzyme. The results of the histological study showed the occurrence of central vein congestion, sinusoidal dilation, inflammatory infiltration and cellular degeneration in group (G2) that received carbimazole (0.02 mg/kg body weight) compared to the control group (G1) that received water and normal food. As for group (G3) treated with carbimazole (0.02 mg/kg body weight) and blackberry aqueous extract (200 mg/kg body weight), it showed mild central vein congestion and sinusoidal dilation compared to group (G4) treated only with blackberry aqueous extract (200 mg/kg body weight), in which the liver tissue appeared closer to its normal state with a clear central vein and mild sinusoidal dilation. | ||
| Keywords | ||
| Hypothyroidism; aqueous extract; Rubus plicatus; male rabbits | ||
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