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Histopathological Changes of Feline Distemper in Persian Kitten: A Case Report | ||
| Al-Qadisiyah Journal of Veterinary Medicine Sciences | ||
| Volume 24, Issue 2, December 2025, Pages 145-149 PDF (489.43 K) | ||
| Document Type: Case Report | ||
| DOI: 10.29079/qjvms.2025.165640.1118 | ||
| Authors | ||
| Omer Khazaal Alhankawe* 1; Yahya Abd Almunaf Ahmed2 | ||
| 1Department of Internal and Preventive Medicine, College of Veterinary Medicine, University of Mosul, Mosul, Iraq | ||
| 2Department of Pharmacy Techniques, Mosul Medical Technical Institute, Northern Technical University, Iraq | ||
| Abstract | ||
| This case report focuses on a Persian kitten that was presented to the Veterinary Teaching Hospital at Mosul University, at the age of 3.5 months, weighing 0.72 kg, unvaccinated, showing fever, lethargy, and anorexia. The kitten became hypothermic as a result of diarrhea, vomiting, and dehydration. Because of severity of the disease, prognosis remained poor despite urgent intensive care. Two hours after the start of therapy, the kitten died without responding. Fecal sample was collected with a sterile swab and tested for feline distemper virus antigen using a commercial immunochromatographic test. DNA was extracted from feces for PCR diagnosis. Following kitten's death, a necropsy was performed; tissues of ileum, mesenteric lymph nodes, liver, and spleen were collected and fixed in 10% buffered formalin. These tissues were paraffin-embedded, sectioned at 5 μm, stained with hematoxylin and eosin, and examined by light microscopy. Diagnostic tests confirmed parvovirus infection: the fecal immunochromatographic test was positive, and PCR yielded a 695 bp amplicon. Histopathology revealed characteristic amphophilic intranuclear inclusion bodies marginating chromatin, along with necrosis, inflammatory cell infiltration, and glandular atrophy in the ileum. Similar inclusion bodies, lymphoid depletion, necrosis, and increased fibrosis were present in the mesenteric lymph node and spleen. The liver exhibited inclusion bodies, coagulative hepatocyte necrosis, and inflammation. In conclusion, the histopathological changes confirmed that gastroenteritis was fatal form of feline distemper. This case highlights how the disease is fatal and ongoing threat to unvaccinated kittens. | ||
| Keywords | ||
| Parvovirus; Cats; PCR; Inclusion bodies; Mosul | ||
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