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Study of clinical signs and blood picture in Male Albino Mice exposed to toxic doses of The Insecticide Diazinon | ||
| Al-Anbar Journal of Veterinary Sciences | ||
| Article 1, Volume 3, Issue 2, 2010, Pages 1-11 PDF (173.12 K) | ||
| Authors | ||
| A. K. Talal; A. A. Yousif | ||
| Abstract | ||
| This study has shed a light on the clinical signs and blood picture to different toxic concentration of the insecticide diazinon on 45 Male Albino Mice which divided into three equal groups. First group: (control group) ingested olive oil, Second group:- ingested oily form of diazinon at a dose 10mg/kg body weight. while the third group:- ingested oily form of diazinon at a dose 15mg/kg body weight, these animals were dosed daily for 8 weeks. Various parameters were utilized in evaluating the effects of the insecticide (clinical signs, bodyweight, weight of internal organs and blood pictures). The animals of second and third groups showed different clinical signs included: loss of appetite, sedation, standing still on the corner of the cage, rubbing its nose and face with bothchands, no response to external stimulants, increased salivation,sheavering,paralysis of limbs and diarrhea. This signs increased with the increasing doses and time of exposure while the control group didn’t show any clinical signs. second group showed a significant decrease at (P 0.05) in body weight after two weeks till the end of exposure .while it appeared at first week of exposure for the third group. There was significant increase in mean liver weight of both treatment groups but the third group record higher means in comparison with the second and the control groups. The average weight of spleen showed significant decrease in both treatment groups in comparison with the control one. The average weight of lymph nodes showed a significant increase at (P 0.05) when animals were dosed with diazinon at 10,15 mgkg body weight in comparsion with the control. The white blood cells count (WBCs), showed a significant decrease at (P 0.05) of both treatment when compared with the control group while the decrease in differential WBC in treatment groups, while the decrease was more in third group than second one in comparison with controle group. The decrease were variable in count of neutrophils, monocytes, esinophils according dose of insecticide | ||
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