- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
A Flow Injection Chemiluminescences(FL-CL)Method for Determination of Diclofenac sodium(Voltaren) and Ethambutol HCl as Active ingredient and as pharmaceutical preparations | ||
| journal of kerbala university | ||
| Article 1, Volume 6, Issue 1, 2010, Pages 196-208 PDF (0 K) | ||
| Abstract | ||
| Chemilumescences method was based on inhibition the chemilumescence of luminol-hydrogen peroxide system catalyzed by cobalt ion Co+2 which produces a blue luminescence .In the presence of drugs, cobalt ion(II) reacts immediately with drugs forming inactive complex preventing the catalytic effect of cobalt(II)ion. In this case an inhibition of the (CL) occurs which is proportional to the amount of the drug added. Optimum conditions obtained as follow: acidity of Co+2 (5×10-3 M), concentration of Co+2(0.7µg/ml), concentration of luminol(5×10-4 M), concentration of H2O2(1×10-2 M), volume of Co+2 ( 200µl), flow-rate (3.0 ml/min). The investigate material show no interference effect on the determination of studied drugs, thus the method of direct calibration graph was applied. The linearity of this method for the determination of D.S, ET drugs were in the range(0.985-8.904) (0.990-5.812) (µg/ml, with relative standard deviation RSD% (0.463 , 0.781 %) and detection limits (0.420 , 0.321)µg/ml respectively .The method was applied successfully for the determination of D.S, ET in pharmaceutical preparations with recovery values of 98.480% , 97.510 % respectively . | ||
|
Statistics Article View: 39 PDF Download: 36 |
||