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The Protective Role of The Amino Acid L-theanine in Reducing Induced Oxidative Stress Mediated by Hydrogen Peroxide in Rats | ||
| Journal of Tikrit University For Agriculture Sciences | ||
| Article 1, Volume 13, Issue 4, 2013, Pages 38-46 | ||
| Abstract | ||
| The current study included the knowledge of the effect of the amino acid L-theanine in reducing oxidative stress induced mediated by hydrogen peroxide by raising concentration levels of some antioxidants enzymatic and non-enzymatic reduce lipid peroxidation level in the sera of rats Rattus norvegicus in 3-5 months of age, This study used , 20 white rats, were randomly divided into five groups by (4 mice / group) and were, respectively, the first group: given a standard diet and distilled water (for drinking) and promised the control group. the second Group: given a standard diet and distilled water (for drinking) contains hydrogen peroxide concentration of 0.5% daily for 30 days. The third Group: given a standard diet and distilled water (for drinking) and theanine concentration of 6 mg / kg body weight for 30 days. The fourth Group: given a diet and distilled water (for drinking) contains hydrogen peroxide concentration of 0.5% and theanine concentration of 6 mg / kg body weight for 30 days, and treated fifth group the same manner as the fourth set but use theanine concentration of 3 mg / kg . Results of treatment by H2O2 showed a significant increase in the effectiveness of enzymes Aspartate aminotransferase (AST) ,Alanine aminotransferase (ALT) , Alkaline phosphatase (ALP), and Malondialdehyde(MDA) and Peroxynitrite radical(ONOO-) in the sera of rats compared with the control group, the results also showed the same treatment group reduced significantly in the concentration of glutathione GSH and the effectiveness of the enzyme superoxid dismutase SOD compared with the control group, while the result showed that the treatment acid amino theanine led to a significant decrease in the effectiveness of the enzymes ALT, AST and ALP and the concentration of MDA and the ONOO- in the sera of rats treatment compared with the control group, while the treatment with theanine led to a rise in the concentration of GSH and effectiveness of SOD enzyme compared with the control group, which demonstrates the role of theanine as good antioxidant | ||
| Keywords | ||
| antioxidant; theanine | ||
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